Investigation on new paradigm of clinical physiological monitoring by using wearable devices / 生物医学工程学杂志

As a low-load physiological monitoring technology, wearable devices can provide new methods for monitoring, evaluating and managing chronic diseases, which is a direction for the future development of monitoring technology. However, as a new type of monitoring technology, its clinical application mode and value are still unclear and need to be further explored. In this study, a central monitoring system based on wearable devices was built in the general ward (non-ICU ward) of PLA General Hospital, the value points of clinical application of wearable physiological monitoring technology were analyzed, and the system was combined with the treatment process and applied to clinical monitoring. The system is able to effectively collect data such as electrocardiogram, respiration, blood oxygen, pulse rate, and body position/movement to achieve real-time monitoring, prediction and early warning, and condition assessment. And since its operation from March 2018, 1 268 people (657 patients) have undergone wearable continuous physiological monitoring until January 2020, with data from a total of 1 198 people (632 cases) screened for signals through signal quality algorithms and manual interpretation were available for analysis, accounting for 94.48 % (96.19%) of the total. Through continuous physiological data analysis and manual correction, sleep apnea event, nocturnal hypoxemia, tachycardia, and ventricular premature beats were detected in 232 (36.65%), 58 (9.16%), 30 (4.74%), and 42 (6.64%) of the total patients, while the number of these abnormal events recorded in the archives was 4 (0.63%), 0 (0.00%), 24 (3.80%), and 15 (2.37%) cases. The statistical analysis of sleep apnea event outcomes revealed that patients with chronic diseases were more likely to have sleep apnea events than healthy individuals, and the incidence was higher in men (62.93%) than in women (37.07%). The results indicate that wearable physiological monitoring technology can provide a new monitoring mode for inpatients, capturing more abnormal events and provide richer information for clinical diagnosis and treatment through continuous physiological parameter analysis, and can be effectively integrated into existing medical processes. We will continue to explore the applicability of this new monitoring mode in different clinical scenarios to further enrich the clinical application of wearable technology and provide richer tools and methods for the monitoring, evaluation and management of chronic diseases.

Review of Physiological Parameters Monitoring Technology in the ICU / 中国医疗器械杂志

Physiological parameters monitoring is essential to direct medical staff to evaluate, diagnose and treat critical patients quantitatively. ECG, blood pressure, SpO2, respiratory rate and body temperature are the basic vital signs of patients in the ICU. The measuring methods are relatively mature at present, and the trend is to be wireless and more accurate and comfortable. Hemodynamics, oxygen metabolism and microcirculation should be taken seriously during the treatment of acute critical patients. The related monitoring technology has made significant progress in recent years, the trend is to reduce the trauma and improve the accuracy and usability. With the development of machine vision and data fusion technology, the identification of patient behavior and deterioration has become hot topics. This review is focused on current parameters monitoring technologies, aims to provide reference for future related research.

Exploratory Study of the Prevalence of Major Chronic Disease According to Daily Water Intake and Physiological Parameters related to Dehydration in Korean Elderly: Based on the Sixth Korea National Health and Nutrition Examination Survey (2015)

PURPOSE: The aim of this study was to explore the prevalence of major chronic diseases related to daily oral water intake and to identify the physiological parameters related to dehydration in Korean elderly. METHODS: The data were collected from the sixth Korea Health and Nutrition Examination Survey (KHANES), which was a nationwide and cross-sectional survey in 2015. We analyzed 1,392 participants using t-test and logistic regression. All participants were divided into the adequate water intake (AWI) group and the non-adequate water intake (NAWI) group based on the dietary reference intakes for Koreans. RESULTS: There was a significant difference in the water intake between the AWI (6.8 cups in a day) and NAWI (2.8 cups) groups (p < .001). There was no statistically significant association between the level of water intake and any of the major chronic diseases. Blood urea nitrogen (BUN) and BUN/Creatinine (Cr) ratio were significantly higher in the NAWI group. Especially, BUN/Cr ratio shows that the NAWI group reached dehydration status. Older age (adjusted odd ratio, OR=1.07, 95% confidence interval, CI [1.04–1.10]), female gender (adjusted OR=1.56, 95% CI [1.05–2.33]), lower body mass index (BMI) (adjusted OR=1.00, 95% CI [0.92–1.00]), higher BUN (adjusted OR=1.04, 95% CI [1.01–1.08]), and higher urine specific gravity (USG) (adjusted OR=1.56, 95% CI [1.19–2.05]) were factors associated with the NAWI group. CONCLUSION: The findings suggest that the level of water intake needs to be considered in relation to age, gender, BMI, BUN, and USG. These are sensitive physiological parameters used for predicting dehydration of the elderly according to their daily oral water intake. It would be helpful to develop strategies to prevent dehydration in elderly individuals and enhance their water intake.

Analysis of physiological and biochemical characteristics of SPF Yorkshire and Landrace swine / 中国实验动物学报

Objective To determine the reproductive physiology and blood physiological and biochemical characteristics of SPF Yorkshire and Landrace swine.Methods Ten reproductive physiology parameters,19 blood physiological parameters and 18 blood biochemical parameters in SPF Yorkshire and Landrace swine were measured using conventional methods and the differences between population,between age groups and between both sexes were analyzed.Results There were no significant differences(P>0.05) in reproductive physiology parameters and most blood physiological and biochemical parameters of the SPF Yorkshire and Landrace swine.A few of parameters,such as blood physiological indices GRAN,HGB,RDW,PLT,PCT,and blood biochemical indices ALKP,CHOL,TBIL,BUN,showed significant difference(P<0.05) between populations,between age groups and between both sexes,however,the values of difference were rather small,deviated from the normal range.Conclusion The physiological and biochemical characteristics of SPF Yorkshire and Landrace swine are basically stable and there is no significant difference compared with other laboratory miniature pigs.This study will provide valuable basic data for raising velvet yield,establishment of animal models and evaluating the genetic quality of closed colony.

Progress in research of biorelevant dissolution media / 中国药学杂志

OBJECTIVE: To summarize and analyze the physiological parameters of the gastrointestinal tract, as well as the progress in research of biorelevant dissolution media. METHODS: Related literatures in recent years were reviewed. RESULTS: The biorelevant dissolution media based on physiological relevant information were used to establish the methods of dissolution evaluation in vitro. CONCLUSION: With depth understanding of the physiological parameters of the gastrointestinal tract, in vitro dissolution of dosage form in biorelevant dissolution media could predict in vivo dissolution performance. In addition, biorelevant media were utilized to investigate the food effect on dissolution. Therefore, the liability of evaluating in vitro-in vivo correlation is further improved.

Mathematic model of respiratory mechanics based on monitored physiological parameters / 医用生物力学

Objective To establish a model of respiratory mechanics with consideration of gas exchange and directly correlate with the gas content in blood during mechanical ventilation with the mechanics of respiratory system. Methods By coupling the physiological parameters of respiratory system and blood circulation system, including the molecular numbers of oxygen and carbon dioxide in alveoli and clinically monitored physiological parameters such as gas content, hemoglobin content, heart rate and cardiac output, a mechanical model was constructed to predict those dynamic parameters of gas content, pressure and flow rate in airway and alveoli in continuous breathing cycles. Results The gas content in different locations of a respiratory system was estimated by the model and the sensitivity of gas content in expiration to the undetermined parameters was evaluated. Conclusions The model of respiratory mechanics developed in the study is a preliminary attempt to predict the regulation roles of physiological parameters clinically monitored during mechanical ventilation, which will provide a theoretical support for the design and development of novel respirators in the follow-up experiment.

A Study of the Relationship between Compliance with Therapeutic Regimens and Physiological Parameters of Hemodialysis Patients / 간호학회지

PURPOSE: This study was done to investigate correlations between compliance and physiological parameters of hemodialysis patients. METHOD: The subjects were 102 patients on hemodialysis at 3 hospitals in B city. Data was collected using Shon(1986)'s questionnaire and measuring physiological parameters (serum urea nitrogen, creatinine, hemoglobin, albumin, potassium, phosphorus, interdialytic weight gain). RESULT: Mean scores of compliance with the therapeutic regimen was 4.00+/-0.55 on a 5 point scale. The area of visiting hospitals and taking medicines were shown to have high compliance with therapeutic regimens; on the other hand, the areas concerning diet and symptoms were shown to be low. Interdialytic weight gain and phosphorus were significantly related to the compliance with therapeutic regimens. CONCLUSION: Hemodialysis patients' therapeutic compliance was related to the physiological parameters(potassium, phosphorus, interdialytic weight gain). Therefore, these findings give hemodialysis patients useful information for raising their therapeutic compliance.

A Study of the Relationship between Compliance with Therapeutic Regimens and Physiological Parameters of Hemodialysis Patients / 간호학회지

PURPOSE: This study was done to investigate correlations between compliance and physiological parameters of hemodialysis patients. METHOD: The subjects were 102 patients on hemodialysis at 3 hospitals in B city. Data was collected using Shon(1986)'s questionnaire and measuring physiological parameters (serum urea nitrogen, creatinine, hemoglobin, albumin, potassium, phosphorus, interdialytic weight gain). RESULT: Mean scores of compliance with the therapeutic regimen was 4.00+/-0.55 on a 5 point scale. The area of visiting hospitals and taking medicines were shown to have high compliance with therapeutic regimens; on the other hand, the areas concerning diet and symptoms were shown to be low. Interdialytic weight gain and phosphorus were significantly related to the compliance with therapeutic regimens. CONCLUSION: Hemodialysis patients' therapeutic compliance was related to the physiological parameters(potassium, phosphorus, interdialytic weight gain). Therefore, these findings give hemodialysis patients useful information for raising their therapeutic compliance.

Research and implementation of real-time dynamic display of multiple physiological parameters / 医疗卫生装备

The real-time dynamic display of physiological parameters curve is a key element to observing users' various physiological information directly in telemedicine system. The real-time dynamic display of B/S waveform is realized with ActiveX, DelphiActiveForm and network data communication based on Sockets.

A Study on Physiological Parameter, Physical Health Status, and Health Perception in the Elderly / 성인간호학회지

PURPOSE: The purpose was to investigate the physiological parameter and physical health status and health perception in the elderly, and to find the correlation between these variables. The subjects were 139 in Kyungi senior center. METHOD: The instruments for this study were physiological parameters, which were composed of vital capacity, blood pressure, pulse oxygenation, hand grip power, body fat and physical health status scale developed by researcher, and health perception scale developed by Ware(1976). The data were analyzed by the SPSS-PC 11.0 version. RESULTS: 1) 7.9% of subjects were included in abnormal range of vital capacity, 40.3% were systolic hypertension and 11.5% were diastolic hypertension. And 92.1% were included in normal range of pulse oxygenation, 79.8% were weakened hand grip power, and 10.1% of subjects were included in normal range of body fat. 2) The total mean score of the physical health status was 26.34 of a possible maximum score of 45. The physical health status score of women was lower than man's. 3) The mean score of man's health perception was 24.52 and women's was 20.39 of a possible maximum score of 44. 4) There was a significant positive correlation between hand grip power and physical health status(r=.28, p=.001). And a significant correlation between physical health status and health perception was found (r=.24, p=.004). CONCLUSION: It is concluded that the blood pressure, hand grip power and body fat among the physiological parameters of elderly subjects in Kyungi senior center were included in abnormal range. The factors were related life style. therefore, it is suggested that the health education to change life style for the elderly is needed.

A Study on Physiological Parameters, Health Perception, and Health Behavior of Adults in Kyungi Province Area / 간호학회지

PURPOSE: The purpose was to investigate the physiological parameters and health perception of adults in Kyungi province area, and the correlation between these variables. The subjects were 95 adults who participated voluntarily in the health examination program. Methods: The instruments for this study were physiological parameters, which were composed of blood pressure, blood sugar, and body fat. The health perception scale developed by Ware (1976), and the health practice performance scale developed by Chang et al. (1999). Results: The average blood pressure was 137/85mmHg, the average blood sugar was 108.56mg/dl, and the average body fat arm sunt was 27.08% in males, and 30.07% in females. There were significant negative correlation between health perception and blood sugar (r=-2.36, p=.01), and body fat (r= -2.77, p=.001). There were significant positive correlations between blood pressure and health behavior (r=2.76, p=.001). However a significant correlation between health perception and health behavior was not found. Of the sociodemographic characteristics, sex (F=5.42, p=.01), and marital status (F=3.29, p=.04) were related to blood pressure. Also sex (F=4.17, p=.04) was related to body fat, and sex (t=4.04, p=.03) was related to health perception and disease status (t=4.33, p=.040). Thus having a relationship with health behavior. CONCLUSION: It is suggested that health perception provide important information about health status. However, this study has not shown a correlation between health perception and health behavior. Therefore further research is needed to find the other variables related to health behavior.

The Effects of Chu-ma Therapy on Decreasing Blood Pressure in Essential Hypertension / 간호학회지

The purpose of this study is to evaluate the effects of Chu-ma therapy and to suggest that the therapy is an effective nursing intervention tool to reduce blood pressure. The research design employed was the non-synchronized research method with non- equivalent control group. A total of 30 people with essential hypertension, who were from forty to sixty five years old, participated in the study. The Chu-ma therapy was administered by every day for ten or fifteen minutes for eight weeks from 19, April to 13, June in 1999. In order to evaluate the effects of Chu-ma therapy, blood pressure of the two groups were measured once a week, and physiological parameters (epinephrine, norepinephrine, total cholesterol, HDL-cholesterol, triglycerides) were measured before and after the treatment. Collected data was analyzed by SAS package. The results of this study can be summarized as follows: 1) There were significant decrease in systolic blood pressure and diastolic blood pressure in the experimental group. 2) There were no significant changes in epinephrine, norepinephrine of the two groups. 3) There were significant decrease in total cholesterol and triglycerides, and HDL- cholesterol increased significantly in the experimental group. 4) The effect of Chu-ma therapy on the measured time on the blood pressure in experimental group was as follows: Both of systolic and diastolic blood pressures were significantly decreased after 5weeks. The result proved that Chu-ma therapy is an effective nursing intervention tool for clients with essential hypertenion. However further research is still necessary to compare the effect with the different periods and number of times for Chu-ma therapy.

The design of the network database of tele-monitoring system / 医疗卫生装备

As an important component of multi-physiological-parameter tele-monitoring system, database system is characterized by its large capacity, complex data type and being realtime. According to the design flow of the database, this paper develops a multi-physiological parameter network database with EER concept model and distributed database technology.

Development of a multiparametric remote monitoring system for heart function / 医疗卫生装备

In this paper, a remote monitoring system based on three tiers framework of ″Home-Community-Hospital″ for home monitoring is introduced. Its characteristics include multiuser concurrency operation, multiple testing parameter, real-time interactivity, dependable and secure data communication, high-speed link with database and load balancing. According to user's requirements, various applications can be developed to perfect medical information system based on B/S mode. A portable multiparametric tester based on embedded system has the functions of wireless data transmission and network communication, whose hardware and software designs are modularized.

Effect of the microenvironment of powered air-purifying medical protective hood on the body's physiological parameters / 医疗卫生装备

Environmental physiological method adopted, the ergonomic experiment is to seek the best parameter of the protective hood structural size, on which the structure design of the protective hood will be based, through the analysis of the organic relationship between the microenvironment of power air-purifying medical protective hood and the body's physiological characteristics. The changes of such indexes due to different air currents are analyzed as the oxygen, carbon dioxide, temperature and humidity in the microenvironment. The changes of testees' physiological parameters and their responses to psychological loads and body strengths are paid attention to. The results show the hood can meet the testees' demands with proper air current.

Research of Data Analytic System of Physiological Parameters Detecting Device for Pilots / 医疗卫生装备

Objective To develop data analytic system of physiological parameters detecting device for pilots.Methods By analyzing the demands,the functions of the system were established;adopting module structure and Objective Oriented method,the system structure was designed;and applying modern digital signal processing technique,algorithms were de-veloped.Results The system has following functions: detection of QRS complex wave and breath rate,arrhythmia analyzing,HRV analyzing and synchro-analyzing of multi-parameter.Conclusion The application in many units demonstrates that the system is feasible,stable and reliable.It is useful for flight surgeon to know the physiological state of pilots.